The term cerebral salt wasting (CSW) was introduced before the syndrome of inappropriate Four years later, Schwartz et al. published their landmark paper on SIADH. . Damaraju SC, Rajshekhar V, Chandy MJ: Validation study of a central. Cerebral salt wasting (CSW) is another potential cause of hyponatremia in those with The causes and diagnosis of hyponatremia, causes and treatment of SIADH, and the general Sivakumar V, Rajshekhar V, Chandy MJ. While fluid restriction is the treatment of choice in SIADH, the treatment .. Differential diagnosis of cerebral salt wasting (CSW) vs syndrome of.

Author: Akirg Samular
Country: Seychelles
Language: English (Spanish)
Genre: Medical
Published (Last): 23 January 2017
Pages: 437
PDF File Size: 2.6 Mb
ePub File Size: 5.17 Mb
ISBN: 369-6-83266-746-5
Downloads: 92435
Price: Free* [*Free Regsitration Required]
Uploader: Zolozahn

As extensively reviewed in our review of renal urate transport, we cite four papers that demonstrate the meager effect of saline infusions on FEurate, Table 3 [ 353637salr ]. In turn, increased AVP levels would impair the ability of the kidney to elaborate a dilute urine.

Cedebral salt wasting syndrome following neurosurgical intervention in tuberculous meningitis. Portions of the work discussed in this manuscript were supported by a grant from Otsuka America Pharmaceutical, Inc.

We report a 6-month-old girl with CSWS associated with tuberculous meningoencephalitis. Failure to distinguish properly between these disorders such that therapy indicated for one disorder is inappropriately employed for the other can potentially result in skadh adverse outcome.

Making an accurate diagnosis is important since the therapy of each condition is quite divergent.

Cerebral salt wasting versus SIADH: what difference?

Is fluid restriction harmful? Only in recent years has cerebral salt wasting again come into favour as a distinct entity.


Volume depletion and natriuresis in patients with a ruptured intracranial aneurysm. After several days of pitressin administration, a large increase in urine sodium siadb chloride excretion was noted. Surfeit and deficit of sodium. Abnormal renal urate transport in patients with intracranial disease.

SIADH versus Cerebral Salt Wasting

This differentiation is extremely important because of divergent therapeutic goals of appropriately water restricting those with SIADH and increasing salt and water with RSW to avoid iatrogenic increases in morbidity and mortality. Value of determining urate in hyponatremia.

Is it cerebral or renal salt wasting? Conflicts of Interest The authors declare no conflict of interest. A CT scan of the head without contrast showed evidence of a subarachnoid haemorrhage with extra axial haemorrhage adjacent to both frontal lobes. Mild hyponatremia and risk of sakt in the ambulatory elderly.

As discussed, this is an important change, as RSW would otherwise not be considered in the absence of clinical cerebral disease [ 34 ]. Since this segment normally reabsorbs the bulk of filtered sodium, a small decrease in the efficiency of this segment would result in the delivery of large amounts of sodium to the distal nephron and ultimately into the final urine.

Just as fluid restriction can potentially worsen the underlying condition in CSW, intravenous saline given to patients with SIADH can cause a further lowering of the serum sodium concentration and potentially result in symptomatic hyponatraemia. He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.

These data provide further evidence for the ineffectiveness of the volume approach to evaluating patients with hyponatremia and support the common notion that we cannot assess the volume status of patients with any degree of accuracy.

  EJ080NA 04C PDF

In patients with CSW intravascular volume needs to be vigorously maintained with intravenous saline. In addition the volume expansion leads to decreased proximal sodium reabsorption and urinary sodium excretion is increased and equal to dietary sodium intake. Vasopressin function in the syndrome of inappropriate antidiuresis.

The administration of saline should not affect ve FEurate to any significant cerebtal Table 3and drugs such as atorvastatin and losartan which are known to increase urate excretion have not been shown to have a meaningful effect on the results [ 4445 ]. Neurological manifestations and morbidity of hyponatremia: This potentially deleterious response is the result of SIADH being a disorder in which renal water handling is impaired but renal sodium handling is normal.

FEurate in percentage excretion of the filtered load of urate can be determined by dividing the ratio of urine to plasma urate by the ratio of urine to plasma creatinine and multiplying by Unexpectedly high Frequency of reset osmostat and cerebral-renal salt wasting in non-edematous hyponatremia: Unfortunately, the present volume approach to hyponatremia, which has been in existence for decades, has been inadequate and misleading, in part because of misconceptions that are unsubstantiated by supportive data.

Elevation of urate clearance caused by inappropriate antidiuretic hormone secretion. The volume approach to hyponatremia and perception that RSW is a rare clinical entity should be abandoned in favor of a more open-minded approach that will lead to better diagnosis and treatment of hyponatremic conditions.